Cholesterol homeostasis gsea

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August undefined, 2024

WebApr 6, 2024 · Pathway analysis revealed that fatty acid metabolism, cholesterol homeostasis, and mitochondrial functions were top enriched signatures in CD70 … WebApr 12, 2024 · We explored the effect of thrombin on human aortic smooth muscle cells (HASMCs) and further analyzed its role in the pathogenesis of atherosclerosis (AS). Thrombin-induced differentially expressed genes (DEGs) in HASMCs were identified by analyzing expression profiles from the GEO. Subsequently, enrichment analysis, GSEA, …

Frontiers A Cholesterol Homeostasis-Related Gene Signature Predicts ...

Web胆固醇（cholesterol ）是哺乳动物体内含量最丰富的甾醇类分子，是细胞膜的基本组分之一，能与邻近脂类分子作用调节膜的刚性、流动性和渗透性，或与跨膜蛋白结合维持或改变后者的构象。胆固醇也是氧化甾醇和甾 … WebNov 10, 2024 · Cholesterol homeostasis is essential for health. Cholesterol serves as a precursor of various steroid hormones, bile acids, and vitamin D. Besides, cholesterol is an essential component of cell membrane and provides lipid for cell proliferation. brew k cup without keurig

Integrative analysis of HASMCs gene expression profile revealed …

WebNov 1, 2024 · Conclusion: We constructed and validated a cholesterol homeostasis-related gene signature to predict the prognosis of EC, which correlated to immune infiltration and expected to help the diagnosis ... WebWe now describe a new YAP-independent role for LATS2 in regulating cholesterol homeostasis by restricting the activity of SREBPs, master regulators of cholesterol and lipid metabolism. ... GSEA of the most differentially expressed (fold change >1.5; P-value < 0.05) genes between the livers of wild-type and Lats2-CKO mice fed an HCD, ... Web75 rows · HALLMARK_CHOLESTEROL_HOMEOSTASIS: Systematic name: M5892: Brief description: Genes involved in cholesterol homeostasis. Full description or abstract : Collection: H: Hallmark: Source publication: Pubmed 26771021 Authors: Liberzon … count to 100 with coach meger

Copy number amplification of ENSA promotes the progression of …

The Molecular Signatures Database (MSigDB) hallmark gene …

WebNov 28, 2024 · Moreover, GSEA showed that 24OHC was associated with positive regulation of cholesterol efflux, but negatively associated with gene signatures linked to cholesterol homeostasis, SREBP targets and stem cell proliferation (Fig 5D). A volcano plot of the RNA-seq results revealed significant changes in several target genes of two … WebApr 9, 2012 · Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-loaded macrophages in the arterial wall. We demonstrate that macrophage lipid body formation can be... count to 100 superheroWebJul 2, 2024 · A Novel Role of SMG1 in Cholesterol Homeostasis That Depends Partially on p53 Alternative Splicing by Muyang Li 1,*, Fredrick Philantrope 1, Alexandra Diot 2, Jean-Christophe Bourdon 2 and Patricia Thompson 1,* 1 Department of Pathology, Renaissance School of Medicine, Stony Brook University, New York, NY 11794, USA 2 count to 100 walrus song

"WebDec 23, 2015 · The Molecular Signatures Database (MSigDB) is one of the most widely used and comprehensive databases of gene sets for performing gene set enrichment analysis. Since its creation, MSigDB has grown beyond its roots in metabolic disease and cancer to include >10,000 gene sets. These better represen … " - Cholesterol homeostasis gsea

Cholesterol homeostasis gsea

The Molecular Signatures Database (MSigDB) hallmark gene …

WebHALLMARK_CHOLESTEROL_HOMEOSTASIS: Enrichment Score (ES)-0.51126134: Normalized Enrichment Score (NES)-1.0561393: Nominal p-value: 0.35918856: FDR q … WebDec 23, 2015 · CHOLESTEROL_HOMEOSTASIS: metabolic: cholesterol homeostasis: 28: 74: 22: FATTY_ACID_METABOLISM: metabolic: fatty acid metabolism: 53: 158: 23: …

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WebOct 11, 2024 · We demonstrate that RORγ functions as an essential activator of the entire cholesterol-biosynthesis program, dominating SREBP2 via its binding to cholesterol-biosynthesis genes and its facilitation of the recruitment of SREBP2. WebFeb 10, 2024 · b Enrichment plot of the cholesterol homeostasis pathway after ENSA knockdown in MDA-MB-231 cells. ... GSEA gene set enrichment analysis, NES normalized enrichment score.

Web1. Introduction. Cholesterol is a unique lipid that plays an essential role in membrane biogenesis. In mammals, cholesterol is principally obtained from diet and de novo biosynthesis by the liver and is distributed throughout the body via low-density lipoprotein (LDL) and high-density lipoprotein [1].Nowadays, due to overnutrition and sedentary … WebPancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with a dismal prognosis. PDAC have extensively reprogrammed metabolic characteristics influenced by interactions with normal cells, the effects of the tumor microenvironment and oncogene-mediated cell-autonomous pathways. In this study, we found that among all cancer hallmarks, …

WebNov 5, 2024 · To investigate the roles of cholesterol homeostasis in terminal erythropoiesis, we used a well-established ex vivo mouse fetal liver cell culture system, in which TER119-negative erythroblasts isolated from E14.5 fetal liver (FLCs) were differentiated into enucleated reticulocytes in vitro. ... GSEA of the transcriptome … WebJan 4, 2024 · Gene Set Enrichment Analysis (GSEA) ... Examination of selected transcripts associated with cholesterol homeostasis revealed higher expression of genes …

WebApr 10, 2024 · Since Srebp1 is a master transcription factor for cholesterol synthesis, this increase was potentially due to a compensatory effect on cholesterol production. For lipid degradation pathways, strong decreases in β-oxidation genes were observed in Irs1 and Bcl6 KO livers ( Figure 6 F, upper panel), likely because these livers had the least ...

Webv. t. e. In biology, homeostasis ( British also homoeostasis) (/hɒmɪə (ʊ)ˈsteɪsɪs/) is the state of steady internal, physical, and chemical conditions maintained by living systems. [1] This is the condition of optimal … count to 100 with ice creamWebCholesterol metabolism is altered to enhance the senescence-associated secretory phenotype a, GSEA of differentially expressed genes with a focus on metabolic pathways during DNA damage-induced ... brew kettle ad on facebookWebApr 6, 2024 · In this work, to better understand how Tregs develop and exert suppressive functions in the NPC microenvironment from an integrated multi-omic perspective, we show that CD70+ NPC cells can enhance... brew kettle beer philippinesWeba, GSEA of differentially expressed genes in human OA for the cholesterol homeostasis pathway (left, top) and the mTOR signaling pathway (left, bottom). False discovery rate (q-value) and ... brew kettle biab horizontal couplersWebBackground: Endometrial cancer (EC) is one of the most common gynecological malignancies in women. Cholesterol metabolism has been confirmed to be closely related to tumor proliferation, invasion and metastasis. However, the correlation between cholesterol homeostasis-related genes and prognosis of EC remains unclear.Methods: … brew kettle amherst boy cottWebThe gene set enrichment analysis (GSEA) analysis further supported that Setd2 KO tissues had lower expression of cholesterol homeostasis genes, both in normal liver and tumor tissues (Fig. 3B,C). Considering the increased liver weight and liver/body weight ratio of Setd2 cKO mice (Figs. 2D and 3D), we hypothesized that Setd2 may regulate lipid ... brew kettle amherst oh hours brew kettle amherst ohio