Webmechanism of mutation, which we have termed dynamic mutation,4 is the change (in-crease or decrease) in copy number of the trinucleotide repeat with the rate of change related to the numberofcopies present at any time. This process, in which an initial change to aDNAsequencealters thechanceoffurther changes to it, contrasts with classical or static

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WebJul 18, 2012 · Here we have begun to dissect promoter-specific transcription initiation directed by a reconstituted human Pol II system at single-molecule resolution using … WebDec 26, 2012 · Abstract. Dynamic mutations are those caused by the expansion of existing polymorphic DNA repeat sequences beyond a copy number threshold. These genetic mutations can give rise to dominant, recessive or X-linked disorders, dependent upon the location of the repeat sequence with respect to the genes that are affected by the … birthday greetings in korean

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Web微卫星(Microsatellite)，基因组中的一类短串联重复DNA序列，一般由1-6个核苷酸组成，呈串联重复排列。由于其核心重复单元重复次数差异，微卫星具有群体多态性。微卫星不 … WebOct 1, 2005 · Repeat instability is a dynamic mutation and is defined by both cis -elements and trans -factors. Both germline (parent-to-offspring) and tissue-specific somatic instability occurs. There are ... WebIncreases in repeat-DNA copy number are the molecular basis of a growing list of human genetic diseases, including fragile X syndrome, myotonic dystrophy, Huntington disease and a form of epilepsy. Repeat-DNA sequences undergo a unique process of dynamic mutation, the common properties of which prob … danny chandler death