WebIn this report, we describe a novel GST-containing protein identified and cloned from Drosophila. This 1045 amino acid protein possesses a zinc finger domain with a tandem array of four FLYWCH zinc finger motifs at its N-terminus and a C-terminal domain that shares a 46% homology with GST. The gene maps to chromosome 3 at position 84C6. A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn ) in order to stabilize the fold. It was originally coined to describe the finger-like appearance of a hypothesized structure from the African clawed frog (Xenopus laevis) transcription factor IIIA. However, it has been found to encompass a wide variety of differing protein st…
CDD Conserved Protein Domain Family: FLYWCH_u - National …
WebApr 13, 2024 · Over recent years, several Cys2-His2 (C2H2) domain-containing proteins have emerged as critical players in repairing DNA-double strand breaks. Human FLYWCH1 is a newly characterised nuclear transcription factor with (C2H2)-type zinc-finger DNA-binding domains. Yet, our knowledge about FLYWCH1 is still in its infancy. This study … WebZinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. This entry represents a potential FLYWCH Zn-finger domain … orc 4733.16
Human Gene FLYWCH1 (ENST00000253928.14) Description and …
WebFLYWCH is a C2H2-type zinc finger characterised by five conserved hydrophobic residues, containing the conserved sequence motif: In molecular biology, the FLYWCH zinc finger is a zinc finger domain. It is found in a number of eukaryotic proteins. http://cbsusrv04.tc.cornell.edu/users/ppdb_domain/hmmpfam.aspx?id=550097&eval=1 Webpfam15423 (PSSM ID: 405997): Conserved Protein Domain Family FLYWCH_N, This family is the N-terminus of some FLYWCH-zinc-finger proteins, found in eukaryotes. … orc 4729.51