Organ toxicity definition
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell (cytotoxicity) or … Zobacz więcej "Toxic" and similar words derive from Greek τόξον toxon ("bow"), a reference to the use of poisoned arrows as weapons. This root was chosen because the transliteration of ἰός ios, the usual Classical Greek word … Zobacz więcej There are generally five types of toxicities; chemical, biological, physical, radioactive and behavioural. Disease-causing microorganisms and parasites are toxic in a broad sense but are generally called pathogens rather than toxicants. The … Zobacz więcej Toxicity of a substance can be affected by many different factors, such as the pathway of administration (whether the toxicant is applied to the skin, ingested, inhaled, injected), the time of exposure (a brief encounter or long term), the number of exposures … Zobacz więcej • Agency for Toxic Substances and Disease Registry (ATSDR) • Biological activity Zobacz więcej Toxicity can be measured by its effects on the target (organism, organ, tissue or cell). Because individuals typically have different levels … Zobacz więcej For substances to be regulated and handled appropriately they must be properly classified and labelled. Classification … Zobacz więcej Considering the limitations of the dose-response concept, a novel Abstract Drug Toxicity Index (DTI) has been proposed recently. DTI … Zobacz więcej WitrynaToxicity testing is a systematic evaluation of the toxic effects that an agent can produce; they are not capable of demonstrating absolute safety (Hayes, 2001). Deriving such information requires a range of computational, cell-based, and animal-based methods targeted to anticipate human responses without the use of human subjects.
Organ toxicity definition
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WitrynaKavita Gulati, Arunabha Ray, in Handbook of Toxicology of Chemical Warfare Agents, 2009. I Introduction. Immunotoxicity is defined as adverse effects on the functioning of both local and systemic immune systems that result from exposure to toxic substances including chemical warfare agents. Observations in humans and animal studies have … Witrynaspecific, non lethal target organ/systemic toxicity arising from a single exposure. All significant health effects that can impair function, both reversible and irreversible, immediate and/or delayed are included. 5. Specific target organ/systemic toxicity following a repeated exposure is classified elsewhere in
Witryna3.8.1.1. Specific target organ toxicity (single exposure) is defined as specific, non lethal target organ toxicity arising from a single exposure to a substance or mixture.All significant health effects that can impair function, both reversible and irreversible, immediate and/or delayed and not specifically addressed in sections 3.1 to 3.7 and … Witryna16 maj 2016 · STOT RE 2 includes substances presumed to be toxic following repeated exposure on the basis of evidence from studies in experimental animals. Target organs: For target organ toxicity, all target organs affected by the toxic substance are listed, if known. Secondary effects on other organs should be ignored. Routes of exposure:
Witryna16 sty 2011 · Genetic toxicology, by definition, is the study of how chemical or physical agents affect the intricate process of heredity. Genotoxic chemicals are defined as compounds that are capable of modifying the hereditary material of living cells. ... In some cases, specific target organ toxicity tests are expressly mandated by statutory … Reproductive toxicity refers to the potential risk from a given chemical, physical or biologic agent to adversely affect both male and female fertility as well as offspring development. Reproductive toxicants may adversely affect sexual function, ovarian failure, fertility as well as causing developmental toxicity in the offspring. Lowered effective fertility related to reproductive toxicity relates to bot…
WitrynaThe most complex path to toxicity involves more steps (Figure 3–1).First, the toxicant is delivered to its target or targets (step 1), interacting with endogenous target molecules …
Witryna26 maj 2024 · The below below summarizes GHS classification criteria for specific target organ toxicity following single exposure based on animal studies (i.e, rat). It should be noted that the guidance value C here is not LD50 or LC50. It is usually lower than LD50 or LC50. For example, oral LD50 (rat)=1000mg/kg means that 50% of rats can die at … h1 aimpointWitrynaOrgan Toxicity It may produce both organ toxicity and cancer depending on dose, duration of exposure, and individual susceptibility (Fowler et al., 2015). From: … pinellas county jail commissary listWitrynaEnd organ damage usually refers to damage occurring in major organs fed by the circulatory system (heart, kidneys, brain, eyes) which can sustain damage due to uncontrolled hypertension, hypotension, or hypovolemia. … pinellas county jail inmatesWitrynaThese are typical symptoms of hepatotoxicity. When Dr. Sayers examined Mike, he also observed that he had jaundice, which is a yellow color to the skin and the whites of the eyes. Additional ... pinellas county jail inmate mailh1 allen keyWitryna19 paź 2012 · Abstract. Adverse toxicologic effects are categorized as chemical-based, on-target, or off-target effects. Chemical-based toxicity is defined as toxicity that is related to the physicochemical characteristics of a compound and its effects on cellular organelles, membranes, and/or metabolic pathways. On-target refers to exaggerated … pinellas county jail floridaWitrynaSpecific target organ toxicity following single exposure, category 3 Respiratory tract irritation; Narcotic effects; Not used. with the "skull and crossbones" pictogram; for skin or eye irritation if: the "corrosion" pictogram also appears; the "health hazard" pictogram is used to indicate respiratory sensitization; pinellas county jail email