site stats

Skp2 function

Webbing Skp2 from Cdh1-mediated degradation and localizing a pool of Skp2 to the cytoplasm by impairing its nuclear localiza-tion signal (NLS) function (Gao et al., 2009; Lin et al., … WebbTherefore, inhibition of Skp2 function by small-molecule compounds targeting Skp2-Cks1 interaction is emerging as a promising and novel anti-cancer strategy. In this study, we …

Dioscin: A new potential inhibitor of Skp2 for cancer therapy

WebbSkp2 functions as an oncogene that participates in processes of many cancers. Here, we report a novel Skp2 inhibitor A … Lung cancer is by far the leading cause of cancer death worldwide, and 85% of patients are diagnosed with non-small cell lung cancer (NSCLC), which is still very difficult to treat. Webb1 dec. 2024 · Regulation of Skp2 function by post-translational modifications 3.3.1. Phossphorylation. Phosphorylation is the most abundant modification on Skp2, which … puffin island maine map https://ocsiworld.com

Cells Free Full-Text Reduced SKP2 Expression Adversely …

WebbSKP1 SKP2. Affinity Capture-Western. Affinity Capture-Western. An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or … Webb1 dec. 2024 · As an important member of the Skp2-SCF E3 ligase complex, Skp2 functions on targeting its phosphorylated substrate proteins for ubiquitin-mediated degradation … Webb15 nov. 2007 · S-phase kinase–associated protein 2 (Skp2), an F-box substrate recognition subunit of the SCF ubiquitin ligase complex, recognizes Thr 187 -phosphorylated p27 Kip1 in collaboration with cdc kinase subunit 1 (Cks1) to promote ubiquitination of p27 Kip1 ( 4 – 7 ). p27 Kip1 is accumulated in Skp2-knockout mouse tissues and embryonic … puffin kiwi

Skp2 regulates DNA damage repair and apoptosis via interaction with …

Category:Skp2 in the ubiquitin-proteasome system: A comprehensive review

Tags:Skp2 function

Skp2 function

Inhibition of S-phase kinase-associated protein 2 (Skp2) …

WebbTop, human SIRT3-HA was stably expressed in Skp2 ϩ / ϩ and Skp2 Ϫ / Ϫ MEFs, and its half-life was from publication: SIRT3 Functions in the Nucleus in the Control of Stress … Webb10 maj 2024 · Skp2 largely functions as an oncoprotein, which has been substantially reviewed in [ 13, 15, 16, 17, 18 ]. Recently, it has been reported to be associated with drug …

Skp2 function

Did you know?

WebbPrevious studies have shown that Skp2 plays an important role in governing cell cycle progression and cell survival by promoting the destruction of numerous tumor … Webb25 juni 2024 · Skp2 functions as an oncogene and participates in the processes of NSCLC. Here, we disclose a novel Skp2 inhibitor, which is firstly synthesized by our group based on our previous computer...

WebbThus, SCF SKP2 is a functional E3 ligase in these lung cancer cells, and USP2 regulation of SKP2 substrate stability is in a manner dependent on SKP2. We then mapped the USP2 … Webb23 jan. 2007 · Function. Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell …

WebbSKP2. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. … Webb4 jan. 2012 · Therefore, in this brief review, we summarize the novel functions of Skp2 in the pathogenesis of breast cancer. Moreover, we provide further evidence regarding the …

Webb17 apr. 2001 · Skp2 is a member of the F-box family of substrate-recognition subunits of SCF ubiquitin–protein ligase complexes that has been implicated in the ubiquitin …

Webb5 apr. 2024 · To confirm the function of SKP2 in NF-κB signaling, we generated SKP2-knockout (KO) HEK293T and THP-1 cells using the CRISPR/Cas9 technology (Figure 2A). … puffin island boat trips angleseyWebb31 jan. 2010 · The regulation of cell cycle entry is critical for cell proliferation and tumorigenesis. One of the key players regulating cell cycle progression is the F-box … seattle consulting myanmar co. ltdWebbSkp2, a pivotal component of SCF Skp2 E3 ubiquitin ligase, has been shown to function as an oncogene in GBM invasion that contributes to the EMT process. Thus, we explored … seattle consulting japanWebb3 jan. 2024 · Skp2, a subunit of the Skp1-Cul1-F-box protein (SCF) E3 ubiquitin ligase, exerts its oncogenic function via promotion of the ubiquitination and subsequent … seattle consulting firmsWebb10 apr. 2024 · Interfacial hydrodynamics and entrainment functions of currently used erosion devices 240 Atlas of Dermoscopy: Third Edition 220 Handbook of Green … puffin loafing ledge live camWebbDissecting Skp2 functions in pRb and p53 doubly deficient tumorigenesis Schwartz, E. L., Zhao, H. & Zhu, L. National Cancer Institute 6/3/16 → 5/31/21 Project: Research project prostatic neoplasms carcinogenesis neoplasms castration mice Publications Research output per year 2009 2024 15 Article 1 Review article seattle construction projectsWebb20 dec. 2005 · Indeed, inhibition of Skp2 function with a dominant-negative molecule reduces the ability of EBNA3C to degrade Rb. Skp2 has no detectable effect on Rb levels in the absence of EBNA3C, suggesting that SCF (Skp2) is specifically usurped by EBNA3C for the enhancement of Rb degradation. puffin light sequence