Webbing Skp2 from Cdh1-mediated degradation and localizing a pool of Skp2 to the cytoplasm by impairing its nuclear localiza-tion signal (NLS) function (Gao et al., 2009; Lin et al., … WebbTherefore, inhibition of Skp2 function by small-molecule compounds targeting Skp2-Cks1 interaction is emerging as a promising and novel anti-cancer strategy. In this study, we …
Dioscin: A new potential inhibitor of Skp2 for cancer therapy
WebbSkp2 functions as an oncogene that participates in processes of many cancers. Here, we report a novel Skp2 inhibitor A … Lung cancer is by far the leading cause of cancer death worldwide, and 85% of patients are diagnosed with non-small cell lung cancer (NSCLC), which is still very difficult to treat. Webb1 dec. 2024 · Regulation of Skp2 function by post-translational modifications 3.3.1. Phossphorylation. Phosphorylation is the most abundant modification on Skp2, which … puffin island maine map
Cells Free Full-Text Reduced SKP2 Expression Adversely …
WebbSKP1 SKP2. Affinity Capture-Western. Affinity Capture-Western. An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or … Webb1 dec. 2024 · As an important member of the Skp2-SCF E3 ligase complex, Skp2 functions on targeting its phosphorylated substrate proteins for ubiquitin-mediated degradation … Webb15 nov. 2007 · S-phase kinase–associated protein 2 (Skp2), an F-box substrate recognition subunit of the SCF ubiquitin ligase complex, recognizes Thr 187 -phosphorylated p27 Kip1 in collaboration with cdc kinase subunit 1 (Cks1) to promote ubiquitination of p27 Kip1 ( 4 – 7 ). p27 Kip1 is accumulated in Skp2-knockout mouse tissues and embryonic … puffin kiwi